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Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.

Swan MK, Hansen T, Schönheit P, Davies C
Biochemistry 43 14088-95 (2004)
Cited: 15 times
EuropePMC logo PMID: 15518558

Abstract

The crystal structure of a dual-specificity phosphoglucose/phosphomannose isomerase from the crenarchaeon Pyrobaculum aerophilum (PaPGI/PMI) has been determined in complex with glucose 6-phosphate at 1.16 A resolution and with fructose 6-phosphate at 1.5 A resolution. Subsequent modeling of mannose 6-phosphate (M6P) into the active site of the enzyme shows that the PMI activity of this enzyme may be due to the additional space imparted by a threonine. In PGIs from bacterial and eukaryotic sources, which cannot use M6P as a substrate, the equivalent residue is a glutamine. The increased space may permit rotation of the C2-C3 bond in M6P to facilitate abstraction of a proton from C2 by Glu203 and, after a further C2-C3 rotation of the resulting cis-enediolate, re-donation of a proton to C1 by the same residue. A proline residue (in place of a glycine in PGI) may also promote PMI activity by positioning the C1-O1 region of M6P. Thus, the PMI reaction in PaPGI/PMI probably uses a cis-enediol mechanism of catalysis, and this activity appears to arise from a subtle difference in the architecture of the enzyme, compared to bacterial and eukaryotic PGIs.

Reviews - 1x9h mentioned but not cited (1)

  1. Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation. Bräsen C, Esser D, Rauch B, Siebers B. Microbiol Mol Biol Rev 78 89-175 (2014)

Articles - 1x9h mentioned but not cited (1)

  1. Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv. Anand K, Mathur D, Anant A, Garg LC. Acta Crystallogr Sect F Struct Biol Cryst Commun 66 490-497 (2010)


Reviews citing this publication (2)

  1. Unusual pathways and enzymes of central carbohydrate metabolism in Archaea. Siebers B, Schönheit P. Curr Opin Microbiol 8 695-705 (2005)
  2. Multifunctional enzymes in archaea: promiscuity and moonlight. Jia B, Cheong GW, Zhang S. Extremophiles 17 193-203 (2013)

Articles citing this publication (11)

  1. Substrate specificity of a mannose-6-phosphate isomerase from Bacillus subtilis and its application in the production of L-ribose. Yeom SJ, Ji JH, Kim NH, Park CS, Oh DK. Appl Environ Microbiol 75 4705-4710 (2009)
  2. Binding of 5-phospho-D-arabinonohydroxamate and 5-phospho-D-arabinonate inhibitors to zinc phosphomannose isomerase from Candida albicans studied by polarizable molecular mechanics and quantum mechanics. Roux C, Gresh N, Perera LE, Piquemal JP, Salmon L. J Comput Chem 28 938-957 (2007)
  3. Evidence supporting a cis-enediol-based mechanism for Pyrococcus furiosus phosphoglucose isomerase. Berrisford JM, Hounslow AM, Akerboom J, Hagen WR, Brouns SJ, van der Oost J, Murray IA, Michael Blackburn G, Waltho JP, Rice DW, Baker PJ. J Mol Biol 358 1353-1366 (2006)
  4. Identification of amino acid residues important for the phosphomannose isomerase activity of PslB in Pseudomonas aeruginosa PAO1. Lee HJ, Chang HY, Venkatesan N, Peng HL. FEBS Lett 582 3479-3483 (2008)
  5. The reaction mechanism of type I phosphomannose isomerases: new information from inhibition and polarizable molecular mechanics studies. Roux C, Bhatt F, Foret J, de Courcy B, Gresh N, Piquemal JP, Jeffery CJ, Salmon L. Proteins 79 203-220 (2011)
  6. The near-symmetry of proteins. Bonjack-Shterengartz M, Avnir D. Proteins 83 722-734 (2015)
  7. Mutagenesis of catalytically important residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus. Hansen T, Schlichting B, Grötzinger J, Swan MK, Davies C, Schönheit P. FEBS J 272 6266-6275 (2005)
  8. Molecular characterization of a novel thermostable mannose-6-phosphate isomerase from Thermus thermophilus. Yeom SJ, Kim YS, Lim YR, Jeong KW, Lee JY, Kim Y, Oh DK. Biochimie 93 1659-1667 (2011)
  9. Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes. Modlin SJ, Elghraoui A, Gunasekaran D, Zlotnicki AM, Dillon NA, Dhillon N, Kuo N, Robinhold C, Chan CK, Baughn AD, Valafar F. mSystems 6 e0067321 (2021)
  10. Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. Jung WS, Singh RK, Lee JK, Pan CH. PLoS One 8 e72902 (2013)
  11. Crystal structure of phosphomannose isomerase from Candida albicans complexed with 5-phospho-d-arabinonhydrazide. Ahmad L, Plancqueel S, Dubosclard V, Lazar N, Ghattas W, Li de la Sierra-Gallay I, van Tilbeurgh H, Salmon L. FEBS Lett 592 1667-1680 (2018)


Related citations provided by authors (2)

  1. A novel phosphoglucose isomerase/phosphomannose isomerase from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution. Swan MK, Hansen T, Schoenheit P, Davies C To be published -
  2. Crystallization and preliminary X-ray diffraction analysis of phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum. Swan MK, Hansen T, Schoenheit P, Davies C Acta Crystallogr. D Biol. Crystallogr. 60 1481-1483 (2004)

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