EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Systematic name:
DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase
Alternative Name(s):
- AP endonuclease class I
- AP lyase
- AP site-DNA 5'-phosphomonoester-lyase
- Deoxyribonuclease (apurinic or apyrimidinic)
- E. coli endonuclease III
- E.coli endonuclease III
- Endodeoxyribonuclease (apurinic or apyrimidinic)
- Micrococcus luteus UV endonuclease
- Phage-T(4) UV endonuclease
- Phage-T4 UV endonuclease
- X-ray endonuclease III
EC 3.2.2.23: DNA-formamidopyrimidine glycosylase
Reaction catalysed:
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
Systematic name:
DNA glycohydrolase (2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing)
Alternative Name(s):
- 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase
- 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase
- Deoxyribonucleate glycosidase
- Fapy-DNA glycosylase
- Formamidopyrimidine-DNA glycosylase
- Fpg protein
GO terms
Biochemical function:
- class I DNA-(apurinic or apyrimidinic site) endonuclease activity
- metal ion binding
- 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
- DNA N-glycosylase activity
- lyase activity
- hydrolase activity, hydrolyzing N-glycosyl compounds
- hydrolase activity, acting on glycosyl bonds
- hydrolase activity
- oxidized purine nucleobase lesion DNA N-glycosylase activity
- zinc ion binding
- DNA-(apurinic or apyrimidinic site) endonuclease activity
- damaged DNA binding
- DNA binding
- nucleic acid binding
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
IPR015887
Domain description:
DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.8.50
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helicase, Ruva Protein; domain 3
Homology:
Helicase, Ruva Protein; domain 3
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1xc8</span> contains 1 copy of CATH domain <span class='highlight'>1.10.8.50 (Helicase, Ruva Protein; domain 3)</span> in <span class='highlight'>Formamidopyrimidine-DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>. The deposited structure of PDB entry 1xc8 contains 1 copy of CATH domain 1.10.8.50 (Helicase, Ruva Protein; domain 3) in Formamidopyrimidine-DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1xc8_3_A_CATH_1.10.8.50_image-200x200.png)
SCOP annotations
81627
Class:
Small proteins
Fold:
Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:
Glucocorticoid receptor-like (DNA-binding domain)
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1xc8</span> contains 1 copy of SCOP domain <span class='highlight'>81627 (C-terminal, Zn-finger domain of MutM-like DNA repair proteins)</span> in <span class='highlight'>Formamidopyrimidine-DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>. The deposited structure of PDB entry 1xc8 contains 1 copy of SCOP domain 81627 (C-terminal, Zn-finger domain of MutM-like DNA repair proteins) in Formamidopyrimidine-DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1xc8_3_A_SCOP_81627_image-200x200.png)
81626
Class:
All alpha proteins
Fold:
S13-like H2TH domain
Superfamily:
S13-like H2TH domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1xc8</span> contains 1 copy of SCOP domain <span class='highlight'>81626 (Middle domain of MutM-like DNA repair proteins)</span> in <span class='highlight'>Formamidopyrimidine-DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>. The deposited structure of PDB entry 1xc8 contains 1 copy of SCOP domain 81626 (Middle domain of MutM-like DNA repair proteins) in Formamidopyrimidine-DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1xc8_3_A_SCOP_81626_image-200x200.png)
81623
Class:
All beta proteins
Fold:
N-terminal domain of MutM-like DNA repair proteins
Superfamily:
N-terminal domain of MutM-like DNA repair proteins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1xc8</span> contains 1 copy of SCOP domain <span class='highlight'>81623 (N-terminal domain of MutM-like DNA repair proteins)</span> in <span class='highlight'>Formamidopyrimidine-DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>. The deposited structure of PDB entry 1xc8 contains 1 copy of SCOP domain 81623 (N-terminal domain of MutM-like DNA repair proteins) in Formamidopyrimidine-DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1xc8_3_A_SCOP_81623_image-200x200.png)