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Crystal structure of stilbene synthase from Pinus sylvestris, complexed with methylmalonyl CoA

Source organism: Pinus sylvestris
Biochemical function: pinosylvin synthase activity
Biological process: polyketide biosynthetic process
Cellular component: cytoplasm

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EC 2.3.1.146: Pinosylvin synthase

Reaction catalysed:
3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO(2)
Systematic name:
Malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)
Alternative Name(s):
  • Pine stilbene synthase
  • Stilbene synthase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02797
Domain description: Chalcone and stilbene synthases, C-terminal domain
Occurring in:
  1. Pinosylvin synthase
The deposited structure of PDB entry 1xet contains 4 copies of Pfam domain PF02797 (Chalcone and stilbene synthases, C-terminal domain) in Pinosylvin synthase. Showing 1 copy in chain A.

PF00195
Domain description: Chalcone and stilbene synthases, N-terminal domain
Occurring in:
  1. Pinosylvin synthase
The deposited structure of PDB entry 1xet contains 4 copies of Pfam domain PF00195 (Chalcone and stilbene synthases, N-terminal domain) in Pinosylvin synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. Pinosylvin synthase
IPR011141
Domain description: Polyketide synthase, type III
Occurring in:
  1. Pinosylvin synthase
IPR012328
Domain description: Chalcone/stilbene synthase, C-terminal
Occurring in:
  1. Pinosylvin synthase
IPR018088
Domain description: Chalcone/stilbene synthase, active site
Occurring in:
  1. Pinosylvin synthase
IPR001099
Domain description: Chalcone/stilbene synthase, N-terminal
Occurring in:
  1. Pinosylvin synthase
IPR029048
Domain description: Heat shock protein 70kD, C-terminal domain superfamily
Occurring in:
  1. Pinosylvin synthase

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. Pinosylvin synthase
The deposited structure of PDB entry 1xet contains 8 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in Pinosylvin synthase. Showing 2 copies in chain A.

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