› 1xod

X-ray diffraction
1.15Å resolution

Crystal structure of X. tropicalis Spred1 EVH-1 domain

Released:
DOI: 10.2210/pdb1xod/pdb
PDB entry 1xod coloured by chain, front view.
PDB entry 1xod coloured by chain, side view.
PDB entry 1xod coloured by chain, top view.
Source organism: Xenopus tropicalis
Primary publication:
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
Harmer NJ, Sivak JM, Amaya E, Blundell TL
FEBS Lett 579 1161-6 (2005)
PMID: 15710406

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179281 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sprouty-related, EVH1 domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.97 KDa
Source organism: Xenopus tropicalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q66JG9 (Residues: 8-123; Coverage: 29%)
Gene name: spred1
Sequence domains: WH1 domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21
Unit cell:
a: 32.811Å b: 38.193Å c: 79.907Å
α: 90° β: 95.68° γ: 90°
R-values:
R R work R free
0.155 0.154 0.177
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Getting a first clue about SPRED functions.
Bundschu et al. (2007)
2 more

1 mention without citation

Diversity of polyproline recognition by EVH1 domains.
Peterson et al. (2009)