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Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant)

Source organism: Homo sapiens
Biochemical function: hydrolase activity
Biological process: cellular response to oxidative stress
Cellular component: mitochondrial matrix

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EC 3.6.1.17: Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

Reaction catalysed:
P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP
Systematic name:
P(1),P(4)-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Alternative Name(s):
  • 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
  • A-P(4)A hydrolase
  • A-P(4)Aase
  • A-P4A hydrolase
  • A-P4Aase
  • Bis(5'-adenosyl)-tetraphosphatase
  • Bis(5'-guanosyl)-tetraphosphatase
  • Diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase
  • Diadenosine P(1),P(4)-tetraphosphatase
  • Diadenosinetetraphosphatase (asymmetrical)
  • Diguanosinetetraphosphatase (asymmetrical)
  • Dinucleoside tetraphosphatase
  • Dinucleosidetetraphosphatase (asymmetrical)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00293
Domain description: NUDIX domain
Occurring in:
  1. Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
The deposited structure of PDB entry 1xsa contains 1 copy of Pfam domain PF00293 (NUDIX domain) in Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003565
Domain description: Bis(5'-nucleosyl)-tetraphosphatase
Occurring in:
  1. Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
IPR000086
Domain description: NUDIX hydrolase domain
Occurring in:
  1. Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
IPR015797
Domain description: NUDIX hydrolase-like domain superfamily
Occurring in:
  1. Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Structure domain

CATH CATH domain
3.90.79.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nucleoside Triphosphate Pyrophosphohydrolase
Homology: Nucleoside Triphosphate Pyrophosphohydrolase
Occurring in:
  1. Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
The deposited structure of PDB entry 1xsa contains 1 copy of CATH domain 3.90.79.10 (Nucleoside Triphosphate Pyrophosphohydrolase) in Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. Showing 1 copy in chain A.
SCOP SCOP annotation
55812
Class: Alpha and beta proteins (a+b)
Fold: Nudix
Superfamily: Nudix
Occurring in:
  1. Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
The deposited structure of PDB entry 1xsa contains 1 copy of SCOP domain 55812 (MutT-like) in Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. Showing 1 copy in chain A.

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