› › Function and Biology

Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP

Source organism: Homo sapiens
Biochemical function: DNA polymerase activity
Biological process: DNA repair
Cellular component: not assigned

Quick links

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF14791
Domain description: DNA polymerase beta thumb
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of Pfam domain PF14791 (DNA polymerase beta thumb ) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].

PF14792
Domain description: DNA polymerase beta palm
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of Pfam domain PF14792 (DNA polymerase beta palm ) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].

PF10391
Domain description: Fingers domain of DNA polymerase lambda
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of Pfam domain PF10391 (Fingers domain of DNA polymerase lambda) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].

PF14716
Domain description: Helix-hairpin-helix domain
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of Pfam domain PF14716 (Helix-hairpin-helix domain) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].

InterPro InterPro annotations
IPR022312
Domain description: DNA polymerase family X
Occurring in:
  1. DNA polymerase lambda
IPR002008
Domain description: DNA polymerase family X, beta-like
Occurring in:
  1. DNA polymerase lambda
IPR043519
Domain description: Nucleotidyltransferase superfamily
Occurring in:
  1. DNA polymerase lambda
IPR002054
Domain description: DNA-directed DNA polymerase X
Occurring in:
  1. DNA polymerase lambda
IPR027421
Domain description: DNA polymerase lambda lyase domain superfamily
Occurring in:
  1. DNA polymerase lambda
IPR037160
Domain description: DNA polymerase, thumb domain superfamily
Occurring in:
  1. DNA polymerase lambda
IPR029398
Domain description: DNA polymerase beta, thumb domain
Occurring in:
  1. DNA polymerase lambda
IPR019843
Domain description: DNA polymerase family X, binding site
Occurring in:
  1. DNA polymerase lambda
IPR028207
Domain description: DNA polymerase beta, palm domain
Occurring in:
  1. DNA polymerase lambda
IPR018944
Domain description: DNA polymerase lambda, fingers domain
Occurring in:
  1. DNA polymerase lambda
IPR010996
Domain description: DNA polymerase beta-like, N-terminal domain
Occurring in:
  1. DNA polymerase lambda

Structure domains

CATH CATH domains
3.30.210.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 3
Homology: DNA polymerase, thumb domain
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of CATH domain 3.30.210.10 (Beta Polymerase; domain 3) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].
3.30.460.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 2
Homology: Beta Polymerase, domain 2
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of CATH domain 3.30.460.10 (Beta Polymerase; domain 2) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].
1.10.150.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: 5' to 3' exonuclease, C-terminal subdomain
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of CATH domain 1.10.150.20 (DNA polymerase; domain 1) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].
1.10.150.110
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: DNA polymerase beta, N-terminal domain-like
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of CATH domain 1.10.150.110 (DNA polymerase; domain 1) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].
SCOP SCOP annotations
81300
Class: Alpha and beta proteins (a+b)
Fold: Nucleotidyltransferase
Superfamily: Nucleotidyltransferase
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of SCOP domain 81300 (DNA polymerase beta-like) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].
81584
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: PsbU/PolX domain-like
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of SCOP domain 81584 (DNA polymerase beta-like, second domain) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].
47803
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: DNA polymerase beta, N-terminal domain-like
Occurring in:
  1. DNA polymerase lambda
The deposited structure of PDB entry 1xsn contains 1 copy of SCOP domain 47803 (DNA polymerase beta, N-terminal domain-like) in DNA polymerase lambda. Showing 1 copy in chain D [auth A].

Quick links