› 1xv4

Solution NMR

Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles

Released:
DOI: 10.2210/pdb1xv4/pdb
PDB entry 1xv4 coloured by chain, ensemble of 7 models, front view.
PDB entry 1xv4 coloured by chain, ensemble of 7 models, side view.
PDB entry 1xv4 coloured by chain, ensemble of 7 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide.
Japelj B, Pristovsek P, Majerle A, Jerala R
J Biol Chem 280 16955-61 (2005)
PMID: 15687491

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoferricin-H Chain: A
Molecule details ›
Chain: A
Length: 12 amino acids
Theoretical weight: 1.53 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02788 (Residues: 39-49; Coverage: 2%)
Gene names: GIG12, LF, LTF

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

9 review citations

Antimicrobial peptides for therapeutic applications: a review.
Seo et al. (2012)
8 more

1 mention without citation

Antimicrobial Peptides: Mechanisms of Action and Resistance.
Bechinger et al. (2017)