› 1y0r

X-ray diffraction
1.75Å resolution

Crystal structure of the tetrahedral aminopeptidase from P. horikoshii

Released:
DOI: 10.2210/pdb1y0r/pdb
PDB entry 1y0r coloured by chain, front view.
PDB entry 1y0r coloured by chain, side view.
PDB entry 1y0r coloured by chain, top view.
Source organism: Pyrococcus horikoshii
Primary publication:
Crystal structure of TET protease reveals complementary protein degradation pathways in prokaryotes.
Borissenko L, Groll M
J Mol Biol 346 1207-19 (2005)
PMID: 15713475

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dodecamer
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129831 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tetrahedral aminopeptidase Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 39.07 KDa
Source organism: Pyrococcus horikoshii
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O59196 (Residues: 1-353; Coverage: 100%)
Gene names: PH1527, frvX
Sequence domains: M42 glutamyl aminopeptidase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand ARS 1 x ARS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P23
Unit cell:
a: 111.572Å b: 111.572Å c: 111.572Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.227
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Peptidase inhibitors in the MEROPS database.
Rawlings ND. (2010)
26 other articles

7 mentions without citation

MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae.
Robinson et al. (2013)
6 more