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A new form of catalytically inactive phospholipase A2 with an unusual disulphide bridge Cys 32- Cys 49 reveals recognition for N-acetylglucosmine

Source organism: Naja sagittifera
Biochemical function: calcium-dependent phospholipase A2 activity
Biological process: arachidonic acid secretion
Cellular component: extracellular region

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EC 3.1.1.4: Phospholipase A(2)

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Systematic name:
Phosphatidylcholine 2-acylhydrolase
Alternative Name(s):
  • Lecithinase A
  • Phosphatidase
  • Phosphatidolipase
  • Phospholipase A
  • Phospholipase A2

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00068
Domain description: Phospholipase A2
Occurring in:
  1. Acidic phospholipase A2 5
  2. Acidic phospholipase A2 6
The deposited structure of PDB entry 1y75 contains 1 copy of Pfam domain PF00068 (Phospholipase A2) in Acidic phospholipase A2 5. Showing 1 copy in chain A.
The deposited structure of PDB entry 1y75 contains 1 copy of Pfam domain PF00068 (Phospholipase A2) in Acidic phospholipase A2 6. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001211
Domain description: Phospholipase A2
Occurring in:
  1. Acidic phospholipase A2 5
  2. Acidic phospholipase A2 6
IPR016090
Domain description: Phospholipase A2 domain
Occurring in:
  1. Acidic phospholipase A2 5
  2. Acidic phospholipase A2 6
IPR036444
Domain description: Phospholipase A2 domain superfamily
Occurring in:
  1. Acidic phospholipase A2 5
  2. Acidic phospholipase A2 6
IPR033113
Domain description: Phospholipase A2, histidine active site
Occurring in:
  1. Acidic phospholipase A2 5
  2. Acidic phospholipase A2 6
IPR033112
Domain description: Phospholipase A2, aspartic acid active site
Occurring in:
  1. Acidic phospholipase A2 6

Structure domain

CATH CATH domain
1.20.90.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Phospholipase A2
Homology: Phospholipase A2 domain
Occurring in:
  1. Acidic phospholipase A2 5
  2. Acidic phospholipase A2 6
The deposited structure of PDB entry 1y75 contains 1 copy of CATH domain 1.20.90.10 (Phospholipase A2) in Acidic phospholipase A2 5. Showing 1 copy in chain A.
The deposited structure of PDB entry 1y75 contains 1 copy of CATH domain 1.20.90.10 (Phospholipase A2) in Acidic phospholipase A2 6. Showing 1 copy in chain B.

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