Function and Biology

Crystal structure of the titin domains z1z2 in complex with telethonin

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF07679
Domain description: Immunoglobulin I-set domain
Occurring in:
  1. Titin
The deposited structure of PDB entry 1ya5 contains 4 copies of Pfam domain PF07679 (Immunoglobulin I-set domain) in Titin. Showing 2 copies in chain A.

PF09470
Domain description: Telethonin protein
Occurring in:
  1. Telethonin
The deposited structure of PDB entry 1ya5 contains 1 copy of Pfam domain PF09470 (Telethonin protein) in Telethonin. Showing 1 copy in chain C [auth T].

InterPro InterPro annotations
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. Titin
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Titin
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Titin
IPR013098
Domain description: Immunoglobulin I-set
Occurring in:
  1. Titin
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Titin
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Titin
IPR015667
Domain description: Telethonin
Occurring in:
  1. Telethonin
IPR023111
Domain description: Titin-like domain superfamily
Occurring in:
  1. Telethonin

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Titin
The deposited structure of PDB entry 1ya5 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Titin. Showing 2 copies in chain A.
2.20.160.10
Class: Mainly Beta
Architecture: Single Sheet
Topology: titin filament fold
Homology: titin domain like
Occurring in:
  1. Telethonin
The deposited structure of PDB entry 1ya5 contains 1 copy of CATH domain 2.20.160.10 (titin filament fold) in Telethonin. Showing 1 copy in chain C [auth T].