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Structure of Archeabacterial 20S proteasome mutant D9S- PA26 complex

Source organisms:
Biochemical function: threonine-type endopeptidase activity
Biological process: proteolysis
Cellular component: proteasome complex

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EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta

PF02252
Domain description: Proteasome activator PA28, C-terminal
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
The deposited structure of PDB entry 1yar contains 7 copies of Pfam domain PF02252 (Proteasome activator pa28 beta subunit) in Proteasome activator PA28 C-terminal domain-containing protein. Showing 1 copy in chain O.

PF10584
Domain description: Proteasome subunit A N-terminal signature
Occurring in:
  1. Proteasome subunit alpha

InterPro InterPro annotations
IPR000243
Domain description: Peptidase T1A, proteasome beta-subunit
Occurring in:
  1. Proteasome subunit beta
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
IPR019983
Domain description: Peptidase T1A, proteasome beta-subunit, archaeal
Occurring in:
  1. Proteasome subunit beta
IPR019982
Domain description: Proteasome alpha subunit, archaeal
Occurring in:
  1. Proteasome subunit alpha
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
IPR003186
Domain description: Proteasome activator PA28, C-terminal domain
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR036252
Domain description: Proteasome activator superfamily
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR036997
Domain description: Proteasome activator PA28, C-terminal domain superfamily
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR016050
Domain description: Proteasome beta-type subunit, conserved site
Occurring in:
  1. Proteasome subunit beta
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome subunit alpha
IPR000426
Domain description: Proteasome alpha-subunit, N-terminal domain
Occurring in:
  1. Proteasome subunit alpha

Structure domains

CATH CATH domains
3.60.20.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
1.20.120.180
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Proteasome activator pa28, C-terminal domain
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
The deposited structure of PDB entry 1yar contains 7 copies of CATH domain 1.20.120.180 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Proteasome activator PA28 C-terminal domain-containing protein. Showing 1 copy in chain O.
SCOP SCOP annotations
56251
Class: Alpha and beta proteins (a+b)
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
The deposited structure of PDB entry 1yar contains 7 copies of SCOP domain 56251 (Proteasome subunits) in Proteasome subunit beta. Showing 1 copy in chain H.
47217
Class: All alpha proteins
Fold: Four-helical up-and-down bundle
Superfamily: Proteasome activator
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
The deposited structure of PDB entry 1yar contains 7 copies of SCOP domain 47217 (Proteasome activator) in Proteasome activator PA28 C-terminal domain-containing protein. Showing 1 copy in chain O.

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