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Crystal Structure of the Tartronic Semialdehyde Reductase from Salmonella typhimurium LT2

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Biochemical function: NAD binding
Biological process: glyoxylate metabolic process
Cellular component: not assigned

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EC 1.1.1.60: 2-hydroxy-3-oxopropionate reductase

Reaction catalysed:
D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H
Systematic name:
D-glycerate:NAD(P)(+) oxidoreductase
Alternative Name(s):
  • Tartronate semialdehyde reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF14833
Domain description: NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
Occurring in:
  1. Tartronic semialdehyde reductase
The deposited structure of PDB entry 1yb4 contains 2 copies of Pfam domain PF14833 (NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase) in Tartronic semialdehyde reductase. Showing 1 copy in chain A.

PF03446
Domain description: NAD binding domain of 6-phosphogluconate dehydrogenase
Occurring in:
  1. Tartronic semialdehyde reductase
The deposited structure of PDB entry 1yb4 contains 2 copies of Pfam domain PF03446 (NAD binding domain of 6-phosphogluconate dehydrogenase) in Tartronic semialdehyde reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029154
Domain description: 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain
Occurring in:
  1. Tartronic semialdehyde reductase
IPR008927
Domain description: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
  1. Tartronic semialdehyde reductase
IPR013328
Domain description: 6-phosphogluconate dehydrogenase, domain 2
Occurring in:
  1. Tartronic semialdehyde reductase
IPR002204
Domain description: 3-hydroxyisobutyrate dehydrogenase-related, conserved site
Occurring in:
  1. Tartronic semialdehyde reductase
IPR006398
Domain description: 2-hydroxy-3-oxopropionate reductase
Occurring in:
  1. Tartronic semialdehyde reductase
IPR006115
Domain description: 6-phosphogluconate dehydrogenase, NADP-binding
Occurring in:
  1. Tartronic semialdehyde reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Tartronic semialdehyde reductase
IPR015815
Domain description: 3-hydroxyisobutyrate dehydrogenase-related
Occurring in:
  1. Tartronic semialdehyde reductase

Structure domains

CATH CATH domains
1.10.1040.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homology: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Occurring in:
  1. Tartronic semialdehyde reductase
The deposited structure of PDB entry 1yb4 contains 2 copies of CATH domain 1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2) in Tartronic semialdehyde reductase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Tartronic semialdehyde reductase
The deposited structure of PDB entry 1yb4 contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Tartronic semialdehyde reductase. Showing 1 copy in chain A.

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