› 1ynd

X-ray diffraction
1.6Å resolution

Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution

Released:
DOI: 10.2210/pdb1ynd/pdb
PDB entry 1ynd coloured by chain, front view.
PDB entry 1ynd coloured by chain, side view.
PDB entry 1ynd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution.
Kallen J, Sedrani R, Zenke G, Wagner J
J Biol Chem 280 21965-71 (2005)
PMID: 15772070

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand SFA 2 x SFA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM1A
Spacegroup: P212121
Unit cell:
a: 62.6Å b: 65.4Å c: 76.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.163 0.185
Expression system: Escherichia coli str. K-12 substr. W3110

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Citations

7 review citations

The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury.
Halestrap et al. (2015)
6 more

4 mentions without citation

Non-Immunosuppressive Cyclophilin Inhibitors.
Schiene-Fischer et al. (2022)
3 more