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Crystal Structure Of Human Enolase-phosphatase E1 and its complex with a substrate analog

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: L-methionine salvage from methylthioadenosine
Cellular component: cytosol

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EC 3.1.3.77: Acireductone synthase

Reaction catalysed:
(1a) 5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
Systematic name:
5-(methylsulfanyl)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)
Alternative Name(s):
  • E-1 enolase-phosphatase
  • E1

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00702
Domain description: haloacid dehalogenase-like hydrolase
Occurring in:
  1. Enolase-phosphatase E1
The deposited structure of PDB entry 1yns contains 1 copy of Pfam domain PF00702 (haloacid dehalogenase-like hydrolase) in Enolase-phosphatase E1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023943
Domain description: Enolase-phosphatase E1
Occurring in:
  1. Enolase-phosphatase E1
IPR006439
Domain description: HAD hydrolase, subfamily IA
Occurring in:
  1. Enolase-phosphatase E1
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Enolase-phosphatase E1
IPR027511
Domain description: Enolase-phosphatase E1, eukaryotes
Occurring in:
  1. Enolase-phosphatase E1
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Enolase-phosphatase E1

Structure domains

CATH CATH domains
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Enolase-phosphatase E1
The deposited structure of PDB entry 1yns contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in Enolase-phosphatase E1. Showing 1 copy in chain A.
1.10.720.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1
Homology: Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1
Occurring in:
  1. Enolase-phosphatase E1
The deposited structure of PDB entry 1yns contains 1 copy of CATH domain 1.10.720.60 (Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1) in Enolase-phosphatase E1. Showing 1 copy in chain A.
SCOP SCOP annotation
142186
Class: Alpha and beta proteins (a/b)
Fold: HAD-like
Superfamily: HAD-like
Occurring in:
  1. Enolase-phosphatase E1
The deposited structure of PDB entry 1yns contains 1 copy of SCOP domain 142186 (Enolase-phosphatase E1) in Enolase-phosphatase E1. Showing 1 copy in chain A.

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