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The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5)

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: cellular oxidant detoxification
Cellular component: blood microparticle

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00042
Domain description: Globin
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
The deposited structure of PDB entry 1yvq contains 2 copies of Pfam domain PF00042 (Globin) in Hemoglobin subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 1yvq contains 2 copies of Pfam domain PF00042 (Globin) in Hemoglobin subunit beta. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002337
Domain description: Hemoglobin, beta-type
Occurring in:
  1. Hemoglobin subunit beta
IPR002338
Domain description: Hemoglobin, alpha-type
Occurring in:
  1. Hemoglobin subunit alpha
IPR002339
Domain description: Hemoglobin, pi
Occurring in:
  1. Hemoglobin subunit alpha
IPR000971
Domain description: Globin
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
IPR009050
Domain description: Globin-like superfamily
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
IPR012292
Domain description: Globin/Protoglobin
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta

Structure domain

CATH CATH domain
1.10.490.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Globin-like
Homology: Globins
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
The deposited structure of PDB entry 1yvq contains 2 copies of CATH domain 1.10.490.10 (Globin-like) in Hemoglobin subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 1yvq contains 2 copies of CATH domain 1.10.490.10 (Globin-like) in Hemoglobin subunit beta. Showing 1 copy in chain B.
SCOP SCOP annotation
46463
Class: All alpha proteins
Fold: Globin-like
Superfamily: Globin-like
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
The deposited structure of PDB entry 1yvq contains 2 copies of SCOP domain 46463 (Globins) in Hemoglobin subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 1yvq contains 2 copies of SCOP domain 46463 (Globins) in Hemoglobin subunit beta. Showing 1 copy in chain B.

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