› 1ywn

X-ray diffraction
1.71Å resolution

Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine

Released:
DOI: 10.2210/pdb1ywn/pdb
PDB entry 1ywn coloured by chain, front view.
PDB entry 1ywn coloured by chain, side view.
PDB entry 1ywn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.
Miyazaki Y, Matsunaga S, Tang J, Maeda Y, Nakano M, Philippe RJ, Shibahara M, Liu W, Sato H, Wang L, Nolte RT
Bioorg Med Chem Lett 15 2203-7 (2005)
PMID: 15837294

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35968 (Residues: 806-1171; Coverage: 24%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LIF 1 x LIF
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 37.953Å b: 95.595Å c: 95.803Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.23
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives.
Cascioferro et al. (2017)
1 more

46 mentions without citation

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential.
Schepetkin et al. (2021)
45 more