Function and Biology

Ornithine aminotransferase PY00104 from Plasmodium Yoelii

Source organism: Plasmodium yoelii yoelii
Biochemical function: identical protein binding
Biological process: L-proline biosynthetic process
Cellular component: cytoplasm

EC 2.6.1.13: Ornithine aminotransferase

Reaction catalysed:
L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid
Systematic name:
L-ornithine:2-oxo-acid aminotransferase
Alternative Name(s):
  • GabT
  • L-ornithine 5-aminotransferase
  • L-ornithine aminotransferase
  • L-ornithine:alpha-ketoglutarate delta-aminotransferase
  • OAT
  • Ornithine 5-aminotransferase
  • Ornithine delta-transaminase
  • Ornithine ketoacid aminotransferase
  • Ornithine transaminase
  • Ornithine--2-oxoacid aminotransferase
  • Ornithine--alpha-ketoglutarate aminotransferase
  • Ornithine--keto acid aminotransferase
  • Ornithine--keto acid transaminase
  • Ornithine--ketoglutarate aminotransferase
  • Ornithine--oxo acid aminotransferase
  • Ornithine--oxo-acid transaminase
  • Ornithine:alpha-oxoglutarate transaminase

Sequence family

Pfam Protein family (Pfam)
PF00202
Domain description: Aminotransferase class-III
Occurring in:
  1. Ornithine aminotransferase
The deposited structure of PDB entry 1z7d contains 6 copies of Pfam domain PF00202 (Aminotransferase class-III) in Ornithine aminotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005814
Domain description: Aminotransferase class-III
Occurring in:
  1. Ornithine aminotransferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Ornithine aminotransferase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Ornithine aminotransferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Ornithine aminotransferase
IPR010164
Domain description: Ornithine aminotransferase
Occurring in:
  1. Ornithine aminotransferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Ornithine aminotransferase
The deposited structure of PDB entry 1z7d contains 6 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Ornithine aminotransferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Ornithine aminotransferase
The deposited structure of PDB entry 1z7d contains 6 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Ornithine aminotransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
53417
Class: Alpha and beta proteins (a/b)
Fold: PLP-dependent transferase-like
Superfamily: PLP-dependent transferases
Occurring in:
  1. Ornithine aminotransferase
The deposited structure of PDB entry 1z7d contains 6 copies of SCOP domain 53417 (GABA-aminotransferase-like) in Ornithine aminotransferase. Showing 1 copy in chain A.