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Crystal structure of selenomethionine substituted isoflavanone 4'-O-methyltransferase

Source organism: Medicago truncatula
Biochemical function: 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.46: Isoflavone 4'-O-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone
Systematic name:
S-adenosyl-L-methionine:4'-hydroxyisoflavone 4'-O-methyltransferase
Alternative Name(s):
  • 4'-hydroxyisoflavone methyltransferase
  • Isoflavone O-methyltransferase
  • Isoflavone methyltransferase

EC 2.1.1.212: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone = S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
Systematic name:
S-adenosyl-L-methionine:2,4',7-trihydroxyisoflavanone 4'-O-methyltransferase
Alternative Name(s):
  • HI4'OMT
  • HMM1
  • MtIOMT5
  • SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00891
Domain description: O-methyltransferase domain
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
The deposited structure of PDB entry 1zhf contains 1 copy of Pfam domain PF00891 (O-methyltransferase domain) in Isoflavone 4'-O-methyltransferase. Showing 1 copy in chain A.

PF08100
Domain description: Dimerisation domain
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
The deposited structure of PDB entry 1zhf contains 1 copy of Pfam domain PF08100 (Dimerisation domain) in Isoflavone 4'-O-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016461
Domain description: O-methyltransferase COMT-type
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
IPR001077
Domain description: O-methyltransferase domain
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
IPR012967
Domain description: Plant methyltransferase dimerisation domain
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Isoflavone 4'-O-methyltransferase

Structure domains

CATH CATH domains
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
The deposited structure of PDB entry 1zhf contains 1 copy of CATH domain 3.40.50.150 (Rossmann fold) in Isoflavone 4'-O-methyltransferase. Showing 1 copy in chain A.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Isoflavone 4'-O-methyltransferase
The deposited structure of PDB entry 1zhf contains 1 copy of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Isoflavone 4'-O-methyltransferase. Showing 1 copy in chain A.

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