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Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.

Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruìz Y, Bachi A, Kronenberg M, Wilson IA, Degano M
J Immunol 175 977-84 (2005)
Cited: 86 times
EuropePMC logo PMID: 16002697

Abstract

NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha1 helix provides a rationale for the structural basis for the observed Valpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR.

Reviews - 1zhn mentioned but not cited (2)

  1. NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. Joyce S, Girardi E, Zajonc DM. J Immunol 187 1081-1089 (2011)
  2. Presentation of lipid antigens by CD1 glycoproteins. Schiefner A, Wilson IA. Curr Pharm Des 15 3311-3317 (2009)

Articles - 1zhn mentioned but not cited (4)

  1. Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY. J Exp Med 203 699-710 (2006)
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  3. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Proc Natl Acad Sci U S A 115 E1204-E1213 (2018)
  4. What one lipid giveth, another taketh away. Joyce S, Spiller BW, Van Kaer L. Nat Immunol 20 1559-1561 (2019)


Reviews citing this publication (40)

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Articles citing this publication (40)

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  25. Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4. Fletcher JM, Jordan MA, Snelgrove SL, Slattery RM, Dufour FD, Kyparissoudis K, Besra GS, Godfrey DI, Baxter AG. J Immunol 181 3400-3412 (2008)
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  31. The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis. Podbielska M, Levery SB, Hogan EL. Clin Lipidol 6 159-179 (2011)
  32. Liposomes of phosphatidylcholine and cholesterol induce an M2-like macrophage phenotype reprogrammable to M1 pattern with the involvement of B-1 cells. Cruz-Leal Y, Lucatelli Laurindo MF, Osugui L, Luzardo Mdel C, López-Requena A, Alonso ME, Álvarez C, Popi AF, Mariano M, Pérez R, Lanio ME. Immunobiology 219 403-415 (2014)
  33. Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response. Laborde RJ, Sanchez-Ferras O, Luzardo MC, Cruz-Leal Y, Fernández A, Mesa C, Oliver L, Canet L, Abreu-Butin L, Nogueira CV, Tejuca M, Pazos F, Álvarez C, Alonso ME, Longo-Maugéri IM, Starnbach MN, Higgins DE, Fernández LE, Lanio ME. J Immunol 198 2772-2784 (2017)
  34. Design and Evaluation of ω-Hydroxy Fatty Acids Containing α-GalCer Analogues for CD1d-Mediated NKT Cell Activation. Lim C, Kim JH, Baek DJ, Lee JY, Cho M, Lee YS, Kang CY, Chung DH, Cho WJ, Kim S. ACS Med Chem Lett 5 331-335 (2014)
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Related citations provided by authors (1)

  1. Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA Science 277 339-345 (1997)

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