Function and Biology

Structure of Mycobacterium tuberculosis NirA protein

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: 4 iron, 4 sulfur cluster binding
Biological process: sulfate assimilation
Cellular component: peptidoglycan-based cell wall

EC 1.8.7.1: Assimilatory sulfite reductase (ferredoxin)

Reaction catalysed:
Hydrogen sulfide + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H(2)O = sulfite + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H(+)
Systematic name:
Hydrogen-sulfide:ferredoxin oxidoreductase
Alternative Name(s):
  • Ferredoxin-sulfite reductase
  • SIR (gene name)
  • Sulfite reductase (ferredoxin)

Sequence families

Pfam Protein families (Pfam)
PF01077
Domain description: Nitrite and sulphite reductase 4Fe-4S domain
Occurring in:
  1. Sulfite reductase [ferredoxin]
The deposited structure of PDB entry 1zj9 contains 4 copies of Pfam domain PF01077 (Nitrite and sulphite reductase 4Fe-4S domain) in Sulfite reductase [ferredoxin]. Showing 2 copies in chain A.

PF03460
Domain description: Nitrite/Sulfite reductase ferredoxin-like half domain
Occurring in:
  1. Sulfite reductase [ferredoxin]
The deposited structure of PDB entry 1zj9 contains 4 copies of Pfam domain PF03460 (Nitrite/Sulfite reductase ferredoxin-like half domain) in Sulfite reductase [ferredoxin]. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR006066
Domain description: Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site
Occurring in:
  1. Sulfite reductase [ferredoxin]
IPR045854
Domain description: Nitrite and sulphite reductase 4Fe-4S domain-like superfamily
Occurring in:
  1. Sulfite reductase [ferredoxin]
IPR006067
Domain description: Nitrite/sulphite reductase 4Fe-4S domain
Occurring in:
  1. Sulfite reductase [ferredoxin]
IPR005117
Domain description: Nitrite/Sulfite reductase ferredoxin-like domain
Occurring in:
  1. Sulfite reductase [ferredoxin]
IPR036136
Domain description: Nitrite/Sulfite reductase ferredoxin-like domain superfamily
Occurring in:
  1. Sulfite reductase [ferredoxin]

Structure domains

CATH CATH domains
3.30.413.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Sulfite Reductase Hemoprotein; domain 1
Homology: Sulfite Reductase Hemoprotein, domain 1
Occurring in:
  1. Sulfite reductase [ferredoxin]
The deposited structure of PDB entry 1zj9 contains 4 copies of CATH domain 3.30.413.10 (Sulfite Reductase Hemoprotein; domain 1) in Sulfite reductase [ferredoxin]. Showing 2 copies in chain A.
3.90.480.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Sulfite Reductase Hemoprotein; domain 2
Homology: Sulfite Reductase Hemoprotein;Domain 2
Occurring in:
  1. Sulfite reductase [ferredoxin]
The deposited structure of PDB entry 1zj9 contains 2 copies of CATH domain 3.90.480.10 (Sulfite Reductase Hemoprotein; domain 2) in Sulfite reductase [ferredoxin]. Showing 1 copy in chain A.
SCOP SCOP annotations
56015
Class: Alpha and beta proteins (a+b)
Fold: Nitrite and sulphite reductase 4Fe-4S domain-like
Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like
Occurring in:
  1. Sulfite reductase [ferredoxin]
The deposited structure of PDB entry 1zj9 contains 4 copies of SCOP domain 56015 (Nitrite and sulphite reductase 4Fe-4S domain-like) in Sulfite reductase [ferredoxin]. Showing 2 copies in chain A.
55125
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: Nitrite/Sulfite reductase N-terminal domain-like
Occurring in:
  1. Sulfite reductase [ferredoxin]
The deposited structure of PDB entry 1zj9 contains 4 copies of SCOP domain 55125 (Duplicated SiR/NiR-like domains 1 and 3) in Sulfite reductase [ferredoxin]. Showing 2 copies in chain A.