› 1zm6

X-ray diffraction
2.6Å resolution

Crystal structure of the complex formed beween a group I phospholipase A2 and designed penta peptide Leu-Ala-Ile-Tyr-Ser at 2.6A resolution

Released:
DOI: 10.2210/pdb1zm6/pdb
PDB entry 1zm6 coloured by chain, front view.
PDB entry 1zm6 coloured by chain, side view.
PDB entry 1zm6 coloured by chain, top view.
Source organism: Naja sagittifera
Primary publication:
Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.
Singh RK, Singh N, Jabeen T, Sharma S, Dey S, Singh TP
J Drug Target 13 367-74 (2005)
PMID: 16278156

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-548310 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acidic phospholipase A2 3 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.17 KDa
Source organism: Naja sagittifera
UniProt:
  • Canonical: P60045 (Residues: 8-126; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain
designed penta peptide Leu-Ala-Ile-Tyr-Ser Chain: P
Molecule details ›
Chain: P
Length: 5 amino acids
Theoretical weight: 566 Da
Source organism: Naja sagittifera
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 42.624Å b: 42.624Å c: 65.203Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.183 0.232
Expression system: Not provided

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Citations

2 review citations

Survey of the year 2005 commercial optical biosensor literature.
Rich et al. (2006)
1 more