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Crystal structure of D. melanogaster deoxyribonucleoside kinase mutant N64D in complex with dTTP

Source organism: Drosophila melanogaster
Biochemical function: cytidine kinase activity
Biological process: nucleoside phosphate biosynthetic process
Cellular component: mitochondrion

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EC 2.7.1.145: Deoxynucleoside kinase

Reaction catalysed:
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
Systematic name:
ATP:deoxyribonucleoside 5'-phosphotransferase
Alternative Name(s):
  • D. melanogaster deoxynucleoside kinase
  • Dm-dNK
  • Ms-dNK
  • Multifunctional deoxynucleoside kinase
  • Multispecific deoxynucleoside kinase
  • Multisubstrate deoxyribonucleoside kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01712
Domain description: Deoxynucleoside kinase
Occurring in:
  1. Deoxynucleoside kinase
The deposited structure of PDB entry 1zm7 contains 4 copies of Pfam domain PF01712 (Deoxynucleoside kinase) in Deoxynucleoside kinase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR031314
Domain description: Deoxynucleoside kinase domain
Occurring in:
  1. Deoxynucleoside kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Deoxynucleoside kinase
IPR002624
Domain description: Deoxynucleoside kinase
Occurring in:
  1. Deoxynucleoside kinase

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Deoxynucleoside kinase
The deposited structure of PDB entry 1zm7 contains 4 copies of CATH domain 3.40.50.300 (Rossmann fold) in Deoxynucleoside kinase. Showing 1 copy in chain B.

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