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Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: extracellular matrix

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EC 3.4.24.34: Neutrophil collagenase

Reaction catalysed:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
Systematic name:
-
Alternative Name(s):
  • MMP-8
  • Matrix metalloproteinase 8
  • PMNL collagenase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. Neutrophil collagenase
The deposited structure of PDB entry 1zp5 contains 1 copy of Pfam domain PF00413 (Matrixin) in Neutrophil collagenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Neutrophil collagenase
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Neutrophil collagenase
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Neutrophil collagenase
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Neutrophil collagenase
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Neutrophil collagenase

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Neutrophil collagenase
The deposited structure of PDB entry 1zp5 contains 1 copy of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Neutrophil collagenase. Showing 1 copy in chain A.
SCOP SCOP annotation
55528
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Occurring in:
  1. Neutrophil collagenase
The deposited structure of PDB entry 1zp5 contains 1 copy of SCOP domain 55528 (Matrix metalloproteases, catalytic domain) in Neutrophil collagenase. Showing 1 copy in chain A.

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