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X-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolor

Source organism: Sporidiobolus salmonicolor
Biochemical function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological process: not assigned
Cellular component: not assigned

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EC 1.1.1.2: Alcohol dehydrogenase (NADP(+))

Reaction catalysed:
An alcohol + NADP(+) = an aldehyde + NADPH
Systematic name:
Alcohol:NADP(+) oxidoreductase
Alternative Name(s):
  • ALR 1
  • Aldehyde reductase (NADPH)
  • High-K(m) aldehyde reductase
  • Low-K(m) aldehyde reductase
  • NADP(+)-alcohol dehydrogenase
  • NADP(+)-aldehyde reductase
  • NADP(+)-dependent aldehyde reductase
  • NADPH-aldehyde reductase
  • NADPH-dependent aldehyde reductase
  • Nonspecific succinic semialdehyde reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01370
Domain description: NAD dependent epimerase/dehydratase family
Occurring in:
  1. Aldehyde reductase 2
The deposited structure of PDB entry 1zze contains 2 copies of Pfam domain PF01370 (NAD dependent epimerase/dehydratase family) in Aldehyde reductase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001509
Domain description: NAD-dependent epimerase/dehydratase
Occurring in:
  1. Aldehyde reductase 2
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Aldehyde reductase 2

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Aldehyde reductase 2
The deposited structure of PDB entry 1zze contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Aldehyde reductase 2. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Aldehyde reductase 2
The deposited structure of PDB entry 1zze contains 2 copies of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in Aldehyde reductase 2. Showing 1 copy in chain A.

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