› 2byn

X-ray diffraction
2.02Å resolution

Crystal structure of apo AChBP from Aplysia californica

Released:
DOI: 10.2210/pdb2byn/pdb
PDB entry 2byn coloured by chain, front view.
PDB entry 2byn coloured by chain, side view.
PDB entry 2byn coloured by chain, top view.
Source organism: Aplysia californica
Primary publication:
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.
Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y
EMBO J 24 3635-46 (2005)
PMID: 16193063

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 227 amino acids
Theoretical weight: 25.85 KDa
Source organism: Aplysia californica
UniProt:
  • Canonical: Q8WSF8 (Residues: 16-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

3 bound ligands:
Ligand PG4 4 x PG4
Ligand 1PE 1 x 1PE
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 144.153Å b: 146.768Å c: 143.307Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.202

Quick links

Citations

76 review citations

Mammalian nicotinic acetylcholine receptors: from structure to function.
Albuquerque et al. (2009)
75 more

28 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
27 more