› 2ds4

Solution NMR

Solution structure of the filamin domain from human tripartite motif protein 45

Released:
DOI: 10.2210/pdb2ds4/pdb
PDB entry 2ds4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ds4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ds4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Tomizawa T, Koshiba S, Watanabe S, Harada T, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190687 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase TRIM45 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9H8W5 (Residues: 396-501; Coverage: 18%)
Gene names: RNF99, TRIM45
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, restrainted molecular dynamics
Expression system: Not provided

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