› 2dyl

X-ray diffraction
2.45Å resolution

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

Released:
DOI: 10.2210/pdb2dyl/pdb
PDB entry 2dyl coloured by chain, front view.
PDB entry 2dyl coloured by chain, side view.
PDB entry 2dyl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kukimoto-Niino M, Takagi T, Kaminishi T, Uchikubo-Kamo T, Terada T, Matsuzaki O, Shirouzu M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127070 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity mitogen-activated protein kinase kinase 7 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.76 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14733 (Residues: 101-405; Coverage: 73%)
Gene names: JNKK2, MAP2K7, MEK7, MKK7, PRKMK7, SKK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 61.552Å b: 69.635Å c: 84.035Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.283
Expression system: Not provided

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