› 2egn

X-ray diffraction
2.4Å resolution

Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide

Released:
DOI: 10.2210/pdb2egn/pdb
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Source organism: Rattus norvegicus
Primary publication:
Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
Sugi T, Oyama T, Muto T, Nakanishi S, Morikawa K, Jingami H
EMBO J 26 2192-205 (2007)
PMID: 17396155

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162680 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
General receptor for phosphoinositides 1-associated scaffold protein Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.64 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8R4T5 (Residues: 96-189; Coverage: 24%)
Gene names: Grasp, Tamalin
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
mGluR5 C-terminal peptide Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 479 Da
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: I422
Unit cell:
a: 75.61Å b: 75.61Å c: 80.185Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.259 0.273
Expression system: Escherichia coli BL21

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Citations

14 review citations

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
Feng et al. (2009)
13 more

4 mentions without citation

Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
Sugi et al. (2007)
3 more

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