› 2ei8

X-ray diffraction
2.1Å resolution

FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Released:
DOI: 10.2210/pdb2ei8/pdb
PDB entry 2ei8 coloured by chain, front view.
PDB entry 2ei8 coloured by chain, side view.
PDB entry 2ei8 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Suzuki M

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133209 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activated factor Xa heavy chain Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 26.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-467; Coverage: 51%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain Chain: B
Molecule details ›
Chain: B
Length: 54 amino acids
Theoretical weight: 5.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 125-178; Coverage: 12%)
Gene name: F10
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand DT8 1 x DT8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 56.217Å b: 72.19Å c: 79.325Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.25

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