Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169913 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ITK/TSK
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 109 amino acids
Theoretical weight: 12.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q03526 (Residues: 238-344; Coverage: 17%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
Lymphocyte cytosolic protein 2
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 795 Da
Source organism: Mus musculus
Expression system: Not provided
UniProt:
Length: 8 amino acids
Theoretical weight: 795 Da
Source organism: Mus musculus
Expression system: Not provided
UniProt:
- Canonical: Q60787 (Residues: 143-148; Coverage: 1%)
Ligands and Environments
No bound ligands
1 modified residue:
Experiments and Validation Details
wwPDB Validation report is not available for this NMR entry.
Refinement method:
Distance geometry simulated annealing was used for refinement
Expression systems:
- Escherichia coli BL21(DE3)
- Not provided
