› 2evz

Solution NMR

Structure of RNA Binding Domains 3 and 4 of Polypyrimidine Tract Binding Protein

Released:
DOI: 10.2210/pdb2evz/pdb
PDB entry 2evz coloured by chain, ensemble of 20 models, front view.
PDB entry 2evz coloured by chain, ensemble of 20 models, side view.
PDB entry 2evz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the two most C-terminal RNA recognition motifs of PTB using segmental isotope labeling.
Vitali F, Henning A, Oberstrass FC, Hargous Y, Auweter SD, Erat M, Allain FH
EMBO J 25 150-62 (2006)
PMID: 16362043

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polypyrimidine tract-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26599 (Residues: 350-557; Coverage: 37%)
Gene names: PTB, PTBP1
Sequence domains:
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics simulated annealing
Expression system: Escherichia coli

Quick links

Citations

20 review citations

RNA recognition motifs: boring? Not quite.
Cléry et al. (2008)
19 more

9 mentions without citation

Reviewing PTBP1 Domain Modularity in the Pre-Genomic Era: A Foundation to Guide the Next Generation of Exploring PTBP1 Structure-Function Relationships.
Carico et al. (2023)
8 more