› 2ggu

X-ray diffraction
1.9Å resolution

crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with maltotriose

Released:
DOI: 10.2210/pdb2ggu/pdb
PDB entry 2ggu coloured by chain, front view.
PDB entry 2ggu coloured by chain, side view.
PDB entry 2ggu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Contributions of phenylalanine 335 to ligand recognition by human surfactant protein D: ring interactions with SP-D ligands.
Crouch E, McDonald B, Smith K, Cafarella T, Seaton B, Head J
J Biol Chem 281 18008-14 (2006)
PMID: 16636058

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152870 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Pulmonary surfactant-associated protein D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 160 amino acids
Theoretical weight: 17.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35247 (Residues: 223-375; Coverage: 43%)
Gene names: COLEC7, PSPD, SFTP4, SFTPD
Sequence domains:
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P21
Unit cell:
a: 55.73Å b: 108.93Å c: 55.84Å
α: 90° β: 91.12° γ: 90°
R-values:
R R work R free
0.225 0.221 0.248
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pulmonary surfactant: an immunological perspective.
Chroneos et al. (2010)
1 more

4 mentions without citation

Structural features, evolutionary relationships, and transcriptional regulation of C-type lectin-domain proteins in Manduca sexta.
Rao et al. (2015)
3 more