› 2h60

Solution NMR

Solution Structure of Human Brg1 Bromodomain

Released:
DOI: 10.2210/pdb2h60/pdb
PDB entry 2h60 coloured by chain, ensemble of 11 models, front view.
PDB entry 2h60 coloured by chain, ensemble of 11 models, side view.
PDB entry 2h60 coloured by chain, ensemble of 11 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails.
Shen W, Xu C, Huang W, Zhang J, Carlson JE, Tu X, Wu J, Shi Y
Biochemistry 46 2100-10 (2007)
PMID: 17274598

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription activator BRG1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51532 (Residues: 1451-1570; Coverage: 7%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Structure and acetyl-lysine recognition of the bromodomain.
Mujtaba et al. (2007)
22 more

3 mentions without citation

Polybromo-1: the chromatin targeting subunit of the PBAF complex.
Thompson M. (2009)
2 more