› 2hck

X-ray diffraction
3Å resolution

SRC FAMILY KINASE HCK-QUERCETIN COMPLEX

Released:
DOI: 10.2210/pdb2hck/pdb
PDB entry 2hck coloured by chain, front view.
PDB entry 2hck coloured by chain, side view.
PDB entry 2hck coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Src family tyrosine kinase Hck.
Sicheri F, Moarefi I, Kuriyan J
Nature 385 602-9 (1997)
PMID: 9024658

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140251 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase HCK Chains: A, B
Molecule details ›
Chains: A, B
Length: 438 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08631 (Residues: 79-526; Coverage: 83%)
Gene name: HCK
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand QUE 2 x QUE
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 73.5Å b: 93.3Å c: 176.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.311
Expression system: Spodoptera frugiperda

Quick links

Citations

163 review citations

Free radicals in the physiological control of cell function.
Dröge W. (2002)
162 more

27 mentions without citation

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura et al. (2011)
26 more