› 2i7q

X-ray diffraction
1.9Å resolution

Crystal structure of Human Choline Kinase A

Released:
DOI: 10.2210/pdb2i7q/pdb
PDB entry 2i7q coloured by chain, front view.
PDB entry 2i7q coloured by chain, side view.
PDB entry 2i7q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Wasney G, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + choline = ADP + phosphocholine
ATP + ethanolamine = ADP + O-phosphoethanolamine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-543437 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline kinase alpha Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 46.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35790 (Residues: 75-457; Coverage: 84%)
Gene names: CHK, CHKA, CKI
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand UNX 11 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 61.798Å b: 61.798Å c: 218.193Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.278
Expression system: Escherichia coli

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