› 2jtc

Solution NMR

3D structure and backbone dynamics of SPE B

Released:
DOI: 10.2210/pdb2jtc/pdb
PDB entry 2jtc coloured by chain, ensemble of 20 models, front view.
PDB entry 2jtc coloured by chain, ensemble of 20 models, side view.
PDB entry 2jtc coloured by chain, ensemble of 20 models, top view.
Source organism: Streptococcus pyogenes serotype M1
Primary publication:
Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity.
Wang CC, Houng HC, Chen CL, Wang PJ, Kuo CF, Lin YS, Wu JJ, Lin MT, Liu CC, Huang W, Chuang WJ
J Biol Chem 284 10957-67 (2009)
PMID: 19237546

Function and Biology Details

Reaction catalysed: 
Preferential cleavage with hydrophobic residues at P2, P1 and P1'.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142887 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Streptopain Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 27.57 KDa
Source organism: Streptococcus pyogenes serotype M1
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C0J1 (Residues: 146-398; Coverage: 68%)
Gene names: M5005_Spy1735, SPy_2039, speB
Sequence domains: Peptidase C10 family
Structure domains: Peptidase C10, streptopain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Functional aspects of protein flexibility.
Teilum et al. (2009)
2 more

3 mentions without citation

Immunomodulating Enzymes from Streptococcus pyogenes-In Pathogenesis, as Biotechnological Tools, and as Biological Drugs.
Happonen et al. (2024)
2 more