› 2k0e

Solution NMR

A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction

Released:
DOI: 10.2210/pdb2k0e/pdb
PDB entry 2k0e coloured by chain, ensemble of 160 models, front view.
PDB entry 2k0e coloured by chain, ensemble of 160 models, side view.
PDB entry 2k0e coloured by chain, ensemble of 160 models, top view.
Source organism: Homo sapiens
Primary publication:
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Gsponer J, Christodoulou J, Cavalli A, Bui JM, Richter B, Dobson CM, Vendruscolo M
OpenAccess logo Structure 16 736-46 (2008)
PMID: 18462678

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-534402 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: CHARMM
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The role of dynamic conformational ensembles in biomolecular recognition.
Boehr et al. (2009)
14 more

8 mentions without citation

A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Gsponer et al. (2008)
7 more