› 2k9e

Solution NMR

NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide

Released:
DOI: 10.2210/pdb2k9e/pdb
PDB entry 2k9e coloured by chain, ensemble of 20 models, front view.
PDB entry 2k9e coloured by chain, ensemble of 20 models, side view.
PDB entry 2k9e coloured by chain, ensemble of 20 models, top view.
Source organism: Stichodactyla helianthus
Primary publication:
Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.
Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG
Mol Pharmacol 75 762-73 (2009)
PMID: 19122005

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-stichotoxin-She3a Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.42 KDa
Source organism: Stichodactyla helianthus
Expression system: Not provided
UniProt:
  • Canonical: P29187 (Residues: 1-35; Coverage: 100%)

Ligands and Environments

No bound ligands
2 modified residues:
Ligand ZV4 1 x ZV4
Ligand NLE 1 x NLE

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 67%
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

26 review citations

Venoms as a platform for human drugs: translating toxins into therapeutics.
King GF. (2011)
25 more

4 mentions without citation

Antibodies and venom peptides: new modalities for ion channels.
Wulff et al. (2019)
3 more