› 2kge

Solution NMR

NMR Solution Structures of 3,5-dioxohexyl ACP (a triketide mimic) from the actinorhodin polyketide synthase in Streptomyces coelicolor

Released:
DOI: 10.2210/pdb2kge/pdb
PDB entry 2kge coloured by chain, ensemble of 20 models, front view.
PDB entry 2kge coloured by chain, ensemble of 20 models, side view.
PDB entry 2kge coloured by chain, ensemble of 20 models, top view.
Source organism: Streptomyces coelicolor
Primary publication:
Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
Evans SE, Williams C, Arthur CJ, Płoskoń E, Wattana-amorn P, Cox RJ, Crosby J, Willis CL, Simpson TJ, Crump MP
J Mol Biol 389 511-28 (2009)
PMID: 19361520

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169662 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actinorhodin polyketide synthase acyl carrier protein Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.24 KDa
Source organism: Streptomyces coelicolor
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02054 (Residues: 1-86; Coverage: 100%)
Gene names: SCBAC28G1.15, SCO5089
Sequence domains: Phosphopantetheine attachment site
Structure domains: ACP-like

Ligands and Environments

1 bound ligand:
Ligand SXD 1 x SXD
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

7 review citations

The structural role of the carrier protein--active controller or passive carrier.
Crosby et al. (2012)
6 more