› 2kqr

Solution NMR

Solution structure of the N-terminal domain (residues 1-111) of Brugia malayi asparaginyl-tRNA synthetase

Released:
DOI: 10.2210/pdb2kqr/pdb
PDB entry 2kqr coloured by chain, ensemble of 20 models, front view.
PDB entry 2kqr coloured by chain, ensemble of 20 models, side view.
PDB entry 2kqr coloured by chain, ensemble of 20 models, top view.
Source organism: Brugia malayi
Primary publication:
A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase.
Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M
J Mol Biol 405 1056-69 (2011)
PMID: 21134380

Function and Biology Details

Reaction catalysed: 
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Asparagine--tRNA ligase, cytoplasmic Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.67 KDa
Source organism: Brugia malayi
Expression system: Escherichia coli
UniProt:
  • Canonical: P10723 (Residues: 1-111; Coverage: 20%)
Sequence domains: Asparaginal-tRNA synthetase, N-terminal domain
Structure domains: asparaginyl-tRNA synthetase, N-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
Pham et al. (2014)
5 more

3 mentions without citation

Modeling disordered regions in proteins using Rosetta.
Wang et al. (2011)
2 more