› 2mb0

Solution NMR

Solution structure of hnRNP G RRM in complex with the RNA 5'-AUCAAA-3'

Released:
DOI: 10.2210/pdb2mb0/pdb
PDB entry 2mb0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mb0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mb0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation.
Moursy A, Allain FH, Cléry A
OpenAccess logo Nucleic Acids Res 42 6659-72 (2014)
PMID: 24692659

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-543961 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
RNA-binding motif protein, X chromosome, N-terminally processed Chain: B
Molecule details ›
Chain: B
Length: 95 amino acids
Theoretical weight: 10.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P38159 (Residues: 1-95; Coverage: 24%)
Gene names: HNRPG, RBMX, RBMXP1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
RNA_(5'-R(*AP*UP*CP*AP*AP*A)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

13 review citations

The hnRNP family: insights into their role in health and disease.
Geuens et al. (2016)
12 more

3 mentions without citation

Characterization of epitranscriptome reader proteins experimentally and in silico: Current knowledge and future perspectives beyond the YTH domain.
Miller et al. (2023)
2 more