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Solution NMR

A Novel 4/7-Conotoxin LvIA from Conus lividus that Selectively Blocks 3 2 vs. 6/3 2 3 Nicotinic Acetylcholine Receptors

Released:
DOI: 10.2210/pdb2mdq/pdb
PDB entry 2mdq coloured by chain, ensemble of 20 models, front view.
PDB entry 2mdq coloured by chain, ensemble of 20 models, side view.
PDB entry 2mdq coloured by chain, ensemble of 20 models, top view.
Source organism: Conus lividus
Primary publication:
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.
Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P
FASEB J 28 1842-53 (2014)
PMID: 24398291

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-516830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin LvIA Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.68 KDa
Source organism: Conus lividus
Expression system: Not provided
UniProt:
  • Canonical: L8BU87 (Residues: 21-36; Coverage: 43%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

10 review citations

Conotoxins targeting nicotinic acetylcholine receptors: an overview.
Lebbe et al. (2014)
9 more

5 mentions without citation

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins.
Ho et al. (2020)
4 more