› 2mka

Solution NMR

Spatial structure of the Toll-like receptor 3 transmembrane domain in the trimeric state

Released:
DOI: 10.2210/pdb2mka/pdb
PDB entry 2mka coloured by chain, ensemble of 10 models, front view.
PDB entry 2mka coloured by chain, ensemble of 10 models, side view.
PDB entry 2mka coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: an NMR structural study.
Mineev KS, Goncharuk SA, Arseniev AS
FEBS Lett 588 3802-7 (2014)
PMID: 25217833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127481 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 34 amino acids
Theoretical weight: 4.09 KDa
Source organism: Homo sapiens
Expression system: cell-free synthesis
UniProt:
  • Canonical: O15455 (Residues: 698-730; Coverage: 4%)
Gene name: TLR3
Sequence domains: Toll-like receptor 3 trans-membrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 39%
Refinement method: simulated annealing
Expression system: cell-free synthesis

Quick links

Citations

4 review citations

Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses.
Chen et al. (2021)
3 more

2 mentions without citation

Host-pathogen protein-nucleic acid interactions: A comprehensive review.
Jain et al. (2022)
1 more