› 2mtv

Solution NMR

Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA

Released:
DOI: 10.2210/pdb2mtv/pdb
PDB entry 2mtv coloured by chain, ensemble of 20 models, front view.
PDB entry 2mtv coloured by chain, ensemble of 20 models, side view.
PDB entry 2mtv coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA.
Theler D, Dominguez C, Blatter M, Boudet J, Allain FH
OpenAccess logo Nucleic Acids Res 42 13911-9 (2014)
PMID: 25389274

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193047 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
YTH domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.51 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9QY02 (Residues: 347-502; Coverage: 21%)
Gene names: Yt521, Ythdc1
Sequence domains: YT521-B-like domain
RNA_(5'-R(*UP*GP*(6MZ)P*CP*AP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 6 nucleotides
Theoretical weight: 1.89 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand 6MZ 1 x 6MZ

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

69 review citations

Rethinking m6A Readers, Writers, and Erasers.
Meyer et al. (2017)
68 more

4 mentions without citation

Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome.
Huang et al. (2018)
3 more