Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155704 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Stromal cell-derived factor 1
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 8.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: CXCL12, SDF1, SDF1A, SDF1B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Length: 70 amino acids
Theoretical weight: 8.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: CXCL12, SDF1, SDF1A, SDF1B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
C-X-C chemokine receptor type 4
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: CXCR4 Chemokine receptor N terminal
Length: 40 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P61073 (Residues: 1-38; Coverage: 11%)
Sequence domains: CXCR4 Chemokine receptor N terminal
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
89%
Refinement method:
torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli
