› 2nle

X-ray diffraction
1.35Å resolution

Human beta-defensin-1 (Mutant Gln11Ala)

Released:
DOI: 10.2210/pdb2nle/pdb
PDB entry 2nle coloured by chain, front view.
PDB entry 2nle coloured by chain, side view.
PDB entry 2nle coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Studies of the biological properties of human beta-defensin 1.
Pazgier M, Prahl A, Hoover DM, Lubkowski J
J Biol Chem 282 1819-29 (2007)
PMID: 17071614

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 36 amino acids
Theoretical weight: 3.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 34.22Å b: 22.78Å c: 40.15Å
α: 90° β: 108.5° γ: 90°
R-values:
R R work R free
0.154 0.151 0.198
Expression system: Escherichia coli

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Citations

6 review citations

Topical antimicrobials for burn wound infections.
Dai et al. (2010)
5 more