› 2nlw

Solution NMR

Solution structure of the RRM domain of human eukaryotic initiation factor 3b

Released:
DOI: 10.2210/pdb2nlw/pdb
PDB entry 2nlw coloured by chain, ensemble of 16 models, front view.
PDB entry 2nlw coloured by chain, ensemble of 16 models, side view.
PDB entry 2nlw coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit.
ElAntak L, Tzakos AG, Locker N, Lukavsky PJ
J Biol Chem 282 8165-74 (2007)
PMID: 17190833

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157336 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 3 subunit B Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55884 (Residues: 170-274; Coverage: 13%)
Gene names: EIF3B, EIF3S9
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, refinement by restrained molecular dynamics in a hydrated environment
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

A brave new world of RNA-binding proteins.
Hentze et al. (2018)
11 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)