› 2o72

X-ray diffraction
2Å resolution

Crystal Structure Analysis of human E-cadherin (1-213)

Released:
DOI: 10.2210/pdb2o72/pdb
PDB entry 2o72 coloured by chain, front view.
PDB entry 2o72 coloured by chain, side view.
PDB entry 2o72 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.
Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH
J Mol Biol 373 401-11 (2007)
PMID: 17850815

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-537015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-1 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12830 (Residues: 155-367; Coverage: 25%)
Gene names: CDH1, CDHE, UVO
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 5 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 137.341Å b: 41.077Å c: 59.542Å
α: 90° β: 111.15° γ: 90°
R-values:
R R work R free
0.226 0.191 0.234
Expression system: Escherichia coli

Quick links

Citations

13 review citations

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges.
Loh et al. (2019)
12 more

33 mentions without citation

Cadherins in early neural development.
Punovuori et al. (2021)
32 more