› 2pon

Solution NMR

Solution structure of the Bcl-xL/Beclin-1 complex

Released:
DOI: 10.2210/pdb2pon/pdb
PDB entry 2pon coloured by chain, ensemble of 20 models, front view.
PDB entry 2pon coloured by chain, ensemble of 20 models, side view.
PDB entry 2pon coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1.
Feng W, Huang S, Wu H, Zhang M
J Mol Biol 372 223-35 (2007)
PMID: 17659302

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-555024 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beclin-1 Chain: A
Molecule details ›
Chain: A
Length: 23 amino acids
Theoretical weight: 2.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14457 (Residues: 106-128; Coverage: 5%)
Gene names: BECN1, GT197
Sequence domains: Beclin-1 BH3 domain, Bcl-2-interacting
Bcl-2-like protein 1 Chain: B
Molecule details ›
Chain: B
Length: 156 amino acids
Theoretical weight: 17.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07817 (Residues: 1-196; Coverage: 67%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Crosstalk between apoptosis, necrosis and autophagy.
Nikoletopoulou et al. (2013)
33 more

9 mentions without citation

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.
Luna-Vargas et al. (2016)
8 more