› 2q9x

X-ray diffraction
1.7Å resolution

Crystal structure of highly stable mutant Q40P/S47I/H93G of human fibroblast growth factor-1

Released:
DOI: 10.2210/pdb2q9x/pdb
PDB entry 2q9x coloured by chain, front view.
PDB entry 2q9x coloured by chain, side view.
PDB entry 2q9x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Szlachcic A, Zakrzewska M, Krowarsch D, Os V, Helland R, Otlewski J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 34.61Å b: 57.599Å c: 57.716Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.245
Expression system: Escherichia coli

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